New Frontiers in Our Understanding of Lymphatic Malformations of the Head and Neck: Natural History and Basic Research

Otolaryngol Clin North Am. 2018 Feb;51(1):147-158. doi: 10.1016/j.otc.2017.09.002.

Abstract

The future of head and neck lymphatic malformation (HNLM) evaluation and treatment is changing because of 2 decades of clinical research and recent basic science investigation. Basic science investigation using cellular biology and molecular genetics has revealed the genetic cause of some HNLMs, which has created the possibility of medical treatment specific to HNLM. This article summarizes the clinical and basic science research that will likely influence the future of HNLM assessment and treatment.

Keywords: Basic research; Head and neck; Lymphatic malformations; Natural history.

Publication types

  • Review

MeSH terms

  • Biomedical Research / trends
  • Capillaries / abnormalities*
  • Child
  • Female
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / therapy*
  • Humans
  • Lymphangioma / diagnosis*
  • Lymphangioma / therapy*
  • Natural History
  • Pregnancy
  • Prenatal Diagnosis
  • Vascular Malformations / diagnosis*
  • Vascular Malformations / therapy*

Supplementary concepts

  • Capillary Malformations, Congenital, 1