Interleukin-10 stiffens the heart

J Exp Med. 2018 Feb 5;215(2):379-381. doi: 10.1084/jem.20180049. Epub 2018 Jan 18.

Abstract

Cardiac-resident macrophages are a diverse population of cells that have a critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Fibroblasts
  • Heart Failure*
  • Humans
  • Interleukin-10*
  • Macrophages
  • Stroke Volume

Substances

  • Interleukin-10