Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Hum Immunol. 2018 May;79(5):277-282. doi: 10.1016/j.humimm.2018.01.010. Epub 2018 Feb 1.

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127-FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

Keywords: Genomic markers; HLA-identical renal transplants; T and B regulatory cells; Tolerance.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Clinical Protocols
  • Female
  • Follow-Up Studies
  • Gene Expression Profiling
  • Graft Rejection / immunology
  • Graft Rejection / pathology
  • Graft Rejection / prevention & control
  • Graft Survival / immunology
  • HLA Antigens / genetics*
  • HLA Antigens / immunology*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Kidney Transplantation*
  • Living Donors
  • Male
  • Middle Aged
  • T-Lymphocytes, Regulatory / immunology
  • Transplantation Chimera / blood
  • Transplantation Chimera / immunology
  • Transplantation Tolerance / immunology*

Substances

  • HLA Antigens