Radiation Dose-Volume Effects for Liver SBRT

Moyed Miften; Yevgeniy Vinogradskiy; Vitali Moiseenko; Jimm Grimm; Ellen Yorke; Andrew Jackson; Wolfgang A Tomé; Randall K Ten Haken; Nitin Ohri; Alejandra Méndez Romero; Karyn A Goodman; Lawrence B Marks; Brian Kavanagh; Laura A Dawson

doi:10.1016/j.ijrobp.2017.12.290

Radiation Dose-Volume Effects for Liver SBRT

Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):196-205. doi: 10.1016/j.ijrobp.2017.12.290. Epub 2018 Jan 6.

Authors

Affiliations

¹ Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado. Electronic address: Moyed.Miften@ucdenver.edu.
² Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
³ Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
⁴ Department of Radiation Oncology and Molecular Radiology Sciences, Baltimore, Maryland.
⁵ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
⁶ Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.
⁷ Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
⁸ Department of Radiation Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
⁹ Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina.
¹⁰ Radiation Medicine Program, Princess Margaret Cancer Centre and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

Abstract

Stereotactic body radiation therapy (SBRT) has emerged as an effective, noninvasive treatment option for primary liver cancer and metastatic disease occurring in the liver. Although SBRT can be highly effective for establishing local control in hepatic malignancies, a tradeoff exists between tumor control and normal tissue complications. The objective of the present study was to review the normal tissue dose-volume effects for SBRT-induced liver and gastrointestinal toxicities and derive normal tissue complication probability models.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Dose-Response Relationship, Radiation
Gastrointestinal Tract / radiation effects*
Humans
Liver / pathology
Liver / radiation effects*
Liver Neoplasms / diagnostic imaging
Liver Neoplasms / radiotherapy*
Liver Neoplasms / secondary
Models, Biological
Models, Statistical
Models, Theoretical
Organ Size
Organs at Risk / radiation effects*
Radiation Injuries / etiology
Radiosurgery / adverse effects
Radiosurgery / methods*
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding