Group 2 innate lymphocytes at the interface between innate and adaptive immunity

Ann N Y Acad Sci. 2018 Apr;1417(1):87-103. doi: 10.1111/nyas.13604. Epub 2018 Mar 1.

Abstract

Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate localized type 2 immune responses. These ILC2-driven type 2 responses are now recognized in diverse immune processes, different anatomical locations, and homeostatic or pathological settings. ILC2-derived cytokines and cell surface signaling molecules function as key regulators of innate and adaptive immunity. Conversely, ILC2 are governed by their environment. As such, ILC2 form an important nexus of the immune system and may present an attractive target for immune modulation in disease.

Keywords: ILC2; T helper cells; TH2; innate lymphoid cells; type 2 response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / immunology*
  • Animals
  • Cell Differentiation
  • Cytokines / immunology
  • Hormones / immunology
  • Humans
  • Immunity, Innate / immunology*
  • Interleukins / immunology
  • Lipids / immunology
  • Lymphocyte Activation
  • Lymphocyte Subsets / classification
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / immunology*
  • Mice
  • Models, Immunological
  • Neuroimmunomodulation
  • Organ Specificity
  • Receptors, Immunologic / immunology
  • Thymic Stromal Lymphopoietin

Substances

  • Cytokines
  • Hormones
  • Interleukins
  • Lipids
  • Receptors, Immunologic
  • Thymic Stromal Lymphopoietin