'Faith Healing' and 'Subtraction Anxiety' in Unblinded Trials of Procedures: Lessons from DEFER and FAME-2 for End Points in the ISCHEMIA Trial

Circ Cardiovasc Qual Outcomes. 2018 Mar;11(3):e004665. doi: 10.1161/CIRCOUTCOMES.118.004665.
No abstract available

Keywords: bias; clinical trials; coronary artery disease; percutaneous coronary intervention.

MeSH terms

  • Anxiety / diagnosis
  • Anxiety / physiopathology
  • Anxiety / psychology*
  • Bias
  • Cause of Death
  • Disease Progression
  • Endpoint Determination*
  • Faith Healing / psychology*
  • Fractional Flow Reserve, Myocardial
  • Hemodynamics
  • Humans
  • Myocardial Ischemia / diagnosis
  • Myocardial Ischemia / mortality
  • Myocardial Ischemia / physiopathology
  • Myocardial Ischemia / therapy*
  • Percutaneous Coronary Intervention* / adverse effects
  • Percutaneous Coronary Intervention* / mortality
  • Randomized Controlled Trials as Topic / methods*
  • Recovery of Function
  • Research Design*
  • Research Personnel / psychology*
  • Research Subjects / psychology*
  • Risk Factors
  • Time Factors
  • Treatment Outcome