The active role of Ca2+ ions in Aβ-mediated membrane damage

Chem Commun (Camb). 2018 Apr 5;54(29):3629-3631. doi: 10.1039/c8cc01132j.

Abstract

Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.

MeSH terms

  • Amyloid / antagonists & inhibitors
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Calcium / metabolism*
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Fluoresceins / pharmacology
  • Fluorescent Dyes / pharmacology
  • Fura-2 / pharmacology
  • Kinetics
  • Mice
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism*
  • Porosity / drug effects
  • Protein Multimerization / drug effects

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Fluoresceins
  • Fluorescent Dyes
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • 6-carboxyfluorescein
  • Calcium
  • Fura-2