Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer

Gene. 2018 Jul 30:665:1-5. doi: 10.1016/j.gene.2018.04.059. Epub 2018 Apr 22.

Abstract

Circular RNAs (circRNAs) play a crucial role in the occurrence of several diseases including cancers. However, little is known about their role in Non-small cell lung cancer (NSCLC). In the present study, we found that hsa_circ_0075930 expression levels were significantly higher in NSCLC cell lines and tissues. The elevated hsa_circ_0075930 expression was correlated with tumor size (P = 0.001) and Lymph node metastasis (P = 0.038). Functional experiments showed knockdown of hsa_circ_0075930 followed by RNA silencing restrained cell proliferation and induced cell cycle arrest of NSCLC cells. In addition, hsa_circ_0075930 suppression impaired migration and invasion potential by reversing epithelial-to-mesenchymal transition (EMT). These results indicated that hsa_circ_0075930 upregulation may be a critical oncogene and potential new biomarker in NSCLC.

Keywords: Biomarker; Circular RNA; NSCLC; Oncogene; hsa_circ_0079530.

MeSH terms

  • A549 Cells
  • Biomarkers, Tumor* / genetics
  • Biomarkers, Tumor* / metabolism
  • Carcinoma, Non-Small-Cell Lung* / genetics
  • Carcinoma, Non-Small-Cell Lung* / metabolism
  • Carcinoma, Non-Small-Cell Lung* / pathology
  • Cell Cycle Checkpoints*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / metabolism
  • Lung Neoplasms* / pathology
  • Male
  • Neoplasm Invasiveness
  • Oncogenes*
  • RNA, Neoplasm* / genetics
  • RNA, Neoplasm* / metabolism
  • RNA, Untranslated* / genetics
  • RNA, Untranslated* / metabolism

Substances

  • Biomarkers, Tumor
  • RNA, Neoplasm
  • RNA, Untranslated