miR-33: A Metabolic Conundrum

Trends Endocrinol Metab. 2018 Oct;29(10):667-668. doi: 10.1016/j.tem.2018.04.004. Epub 2018 Apr 21.

Abstract

The miR-33 microRNAs (miRNAs) are crucial regulators of cholesterol/lipids, and may represent therapeutic targets for the treatment of atherosclerosis. A recent report by Price et al. showed that miR-33 knockout (KO) mice exhibit obesity, insulin resistance, and increased food intake, suggesting that metabolic regulation by miR-33 is more complex than was previously known.

Keywords: insulin resistance; miR-33; microRNA; obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adiposity
  • Animals
  • Insulin Resistance*
  • Mice
  • Mice, Knockout
  • MicroRNAs*
  • Obesity
  • Tissue Expansion

Substances

  • MicroRNAs
  • Mirn33 microRNA, mouse