Memory circuits: CA2

Curr Opin Neurobiol. 2018 Oct:52:54-59. doi: 10.1016/j.conb.2018.04.015. Epub 2018 May 15.

Abstract

The hippocampus is a central region in the coding of spatial, temporal and episodic memory. Recent discoveries have revealed surprising and complex roles of the small area CA2 in hippocampal function. Lesion studies have revealed that this region is required for social memory formation. Area CA2 is targeted by extra-hippocampal paraventricular inputs that release vasopressin and can act to enhance social memory performance. In vivo recordings have revealed nonconventional activity by neurons in this region that act to both initiate hippocampal sharp-wave ripple events as well as encode spatial information during immobility. Silencing of CA2 pyramidal neurons has revealed that this area also acts to control hippocampal network excitability during encoding, and this balance of excitation and inhibition is disrupted in disease. This review summarizes recent findings and attempts to integrate these results into pre-existing models.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CA2 Region, Hippocampal / physiology*
  • Electrophysiological Phenomena / physiology*
  • Humans
  • Memory / physiology*
  • Pyramidal Cells / physiology*
  • Social Perception*
  • Space Perception / physiology*