Depression is a highly prevalent and severely disabling disease. The treatment effects, intensity and onset time of antidepressants have been highlighted in many studies. Recent studies on the rapid-onset of antidepressant response focused on the effect of a single low dose of intravenous ketamine. However, there are still some problems with treatment, including safety, efficacy, ethics, dose, frequency of administration and their effect in treatment-resistant depression. In the present study, we treated one case of treatment resistant depression with repeated intravenous injections with a low dosage of ketamine.
抑郁症是一类患病率高且危害严重的疾病，抗抑郁药物的疗效强度及起效时间一直备受关注，目前在抗抑郁治疗的快速起效方面研究热点是以低剂量氯胺酮静脉注射治疗，但在氯胺酮使用过程中仍有较多问题，包括安全性、疗效、伦理、给药剂量及频次、在难治性抑郁症患者中的应用等。本研究采用重复低剂量氯胺酮静脉注射的方式成功治疗了一例难治性抑郁症患者，结果安全有效。.
Keywords: Ketamine; Treatment-resistant depression.