Kindr Motors Drive in Meiosis

Courtney M Schroeder; Harmit S Malik

doi:10.1016/j.cell.2018.04.021

Kindr Motors Drive in Meiosis

Cell. 2018 May 3;173(4):813-815. doi: 10.1016/j.cell.2018.04.021.

Authors

Courtney M Schroeder¹, Harmit S Malik²

Affiliations

¹ Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
² Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: hsmalik@fhcrc.org.

PMID: 29727667
DOI: 10.1016/j.cell.2018.04.021

Abstract

The discovery of neocentromere activity by maize knobs heralded the field of meiotic drive, in which selfish genetic elements exploit meiotic asymmetry to enhance their propagation. A new study reveals the long-awaited basis of this meiotic drive: cytoskeletal motors enable neocentromeric knobs to achieve favorable meiotic positioning and preferential inheritance.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Centromere
Kinesins*
Meiosis
Zea mays / genetics*

Substances

Kinesins

Grants and funding

R01 GM074108/GM/NIGMS NIH HHS/United States