Retinal vasculitis associated with CREST syndrome

Sungjae Yang; Laura J Kopplin; James T Rosenbaum

doi:10.1016/j.ajoc.2018.02.022

Retinal vasculitis associated with CREST syndrome

Am J Ophthalmol Case Rep. 2018 Mar 2:10:185-188. doi: 10.1016/j.ajoc.2018.02.022. eCollection 2018 Jun.

Authors

Sungjae Yang^{1

2}, Laura J Kopplin³, James T Rosenbaum^{2

4

5}

Affiliations

¹ Department of Ophthalmology, Gangneung Asan Hospital, Ulsan University, Gangneung, South Korea.
² Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
³ Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, WI 53226, USA.
⁴ Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
⁵ Legacy Devers Eye Institute, 1040 NW 22nd Ave, Suite 200, Portland, OR 97210, USA.

Abstract

Purpose: To report two cases of retinal vasculitis associated with CREST syndrome, a novel ocular finding.

Observations: We report two cases of patients with CREST syndrome with ocular inflammatory disease. Patient 1 presented with a right unilateral panuveitis with extensive retinal vasculitis and evidence of prior uveitis in the contralateral eye. Patient 2 presented with a left branch retinal artery occlusion and bilateral retinal vasculitis. Both patients underwent treatment with prednisone and mycophenolate motefil.

Conclusions and importance: Retinal vasculitis has not been previously reported in CREST syndrome. Prompt therapy with immunomodulatory therapy can potentially minimize ocular morbidity.

Keywords: CREST syndrome; Retinal vasculitis.

Publication types

Case Reports

Grants and funding

R01 EY026572/EY/NEI NIH HHS/United States