Bone Mineral Content and Density in Indian Children with Congenital Adrenal Hyperplasia

Indian Pediatr. 2018 Oct 15;55(10):880-882. Epub 2018 Jun 13.

Abstract

Objective: To study the bone mineral content and density in children with congenital adrenal hyperplasia (CAH).

Methods: 35 children with congenital adrenal hyperplasia and 35 healthy controls. Bone mineral content and density were studied by Dual Energy X-ray absorptiometry.

Results: The mean (SD) of lumbar spine bone mineral density (g/cm2) [0.590 (0.100) vs 0.589 (0.088) (P=0.97)], total Body less head bone mineral density (g/cm2) [0.536 (0.090) vs 0.548 (0.111) (P=0.64)], lumbar spine bone mineral content (g) [29.85 (27.63) vs 31.03 (29.19) (P=0.86)], and total body less head bone mineral content (g) [254.27 (281.25) vs 273.07 (330.71) (P=0.79)] were not different between children with CAH and controls, respectively.

Conclusions: Bone mineral density and content in children with congenital adrenal hyperplasia are maintained in the normal range.

MeSH terms

  • Absorptiometry, Photon
  • Adolescent
  • Adrenal Hyperplasia, Congenital / complications*
  • Adrenal Hyperplasia, Congenital / drug therapy
  • Bone Density*
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Glucocorticoids / adverse effects*
  • Glucocorticoids / therapeutic use
  • Humans
  • India
  • Infant
  • Lumbar Vertebrae / physiopathology
  • Male
  • Osteoporosis / chemically induced

Substances

  • Glucocorticoids