Physiological Glucocorticoid Replacement in Adrenal Insufficiency: Does It Fix the Broken Clock?

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3511-3513. doi: 10.1210/jc.2018-01245.

Authors

Matthew R Brown¹, Aleksey V Matveyenko^{1

2}

Affiliations

¹ Department of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, Minnesota.
² Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, Minnesota.

Abstract

Chronotherapeutic glucocorticoid replacement modulates clock gene expression.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Adrenal Insufficiency*
Circadian Rhythm
Dexamethasone
Glucocorticoids*
Humans

Substances

Glucocorticoids
Dexamethasone

Grants and funding

R01 DK098468/DK/NIDDK NIH HHS/United States