A dLight-ful New View of Neuromodulation

Caitlin V Cosme; Gates K Palissery; Talia N Lerner

doi:10.1016/j.tins.2018.07.004

A dLight-ful New View of Neuromodulation

Trends Neurosci. 2018 Sep;41(9):566-568. doi: 10.1016/j.tins.2018.07.004. Epub 2018 Jul 25.

Authors

Caitlin V Cosme¹, Gates K Palissery¹, Talia N Lerner²

Affiliations

¹ Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
² Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: talia.lerner@northwestern.edu.

Abstract

Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

Keywords: dopamine; genetically encoded indicators; imaging; neuromodulation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Dopamine*
Neurons*
Neurotransmitter Agents

Substances

Neurotransmitter Agents
Dopamine

Grants and funding

R00 MH109569/MH/NIMH NIH HHS/United States