'NOTCHing up' the In Vitro Production of Dendritic Cells

Martin Guilliams; Charlotte L Scott

doi:10.1016/j.it.2018.08.002

'NOTCHing up' the In Vitro Production of Dendritic Cells

Trends Immunol. 2018 Oct;39(10):765-767. doi: 10.1016/j.it.2018.08.002. Epub 2018 Aug 24.

Authors

Martin Guilliams¹, Charlotte L Scott²

Affiliations

¹ Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: martin.guilliams@irc.vib-ugent.be.
² Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: charlotte.scott@irc.vib-ugent.be.

PMID: 30150090
DOI: 10.1016/j.it.2018.08.002

Abstract

Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Dendritic Cells*
Humans
Mice
Signal Transduction*

Grants and funding

Wellcome Trust/United Kingdom