Pericytes: The Brain's Very First Responders?

Neuron. 2018 Oct 10;100(1):11-13. doi: 10.1016/j.neuron.2018.09.033.

Abstract

Infection can negatively impact brain functions. Here, Duan et al. (2018) show that specific PDGFRβ-expressing cell subtypes of the neurovascular unit release the chemokine CCL2 rapidly after systemic infection, leading to increased neural excitability.

Publication types

  • Comment

MeSH terms

  • Brain
  • Chemokine CCL2
  • Emergency Responders*
  • Humans
  • Neurons
  • Pericytes*
  • Receptor, Platelet-Derived Growth Factor beta

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • Receptor, Platelet-Derived Growth Factor beta