Tissue Unit-ed: Lung Cells Team up to Drive Alveolar Macrophage Development

Charlotte L Scott; Martin Guilliams

doi:10.1016/j.cell.2018.10.031

Tissue Unit-ed: Lung Cells Team up to Drive Alveolar Macrophage Development

Cell. 2018 Nov 1;175(4):898-900. doi: 10.1016/j.cell.2018.10.031.

Authors

Charlotte L Scott¹, Martin Guilliams²

Affiliations

¹ Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Centre for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: charlotte.scott@irc.vib-ugent.be.
² Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Centre for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: martin.guilliams@irc.vib-ugent.be.

PMID: 30388447
DOI: 10.1016/j.cell.2018.10.031

Abstract

Using single-cell RNA sequencing of both immune and non-immune cells in the developing lung, Cohen et al. map candidate cell-cell interactions during alveolar macrophage development. This revealed potential cross-talk between epithelial cells, ILC2s, basophils, and the developing macrophages, which were validated both in vitro and in vivo.

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MeSH terms

Basophils*
Cell Communication
Immunity, Innate
Lung
Lymphocytes
Macrophages
Macrophages, Alveolar*