Hold the door: hPMCA1/neuroplastin interactions regulate Ca2+-binding site accessibility

Abstract

In a September 2018 paper published in Nature Communications, Gong et al. identified the domains through which human PMCA1 and neuroplastin (NPTN) interact. Upon binding, hPMCA1 TM domains separate T110 in TM1 and A370 in TM3 to reveal the Ca²⁺-binding site. Thus, NPTN is able to directly modulate the accessibility of cytosolic Ca²⁺ to PMCA.