Functional and Mechanistic Insights into the Pathogenesis of P63-Associated Disorders

Maria Rosaria Mollo; Luisa Cirillo; Claudia Russo; Dario Antonini; Caterina Missero

doi:10.1016/j.jisp.2018.10.004

Functional and Mechanistic Insights into the Pathogenesis of P63-Associated Disorders

J Investig Dermatol Symp Proc. 2018 Dec;19(2):S98-S100. doi: 10.1016/j.jisp.2018.10.004.

Authors

Maria Rosaria Mollo¹, Luisa Cirillo¹, Claudia Russo², Dario Antonini³, Caterina Missero⁴

Affiliations

¹ Center for Genetic Engineering, Napoli, Italy.
² Center for Genetic Engineering, Napoli, Italy; European School of Molecular Medicine, University of Milan, Italy.
³ Center for Genetic Engineering, Napoli, Italy; Department of Biology, University of Naples Federico II, Napoli, Italy.
⁴ Center for Genetic Engineering, Napoli, Italy; Department of Biology, University of Naples Federico II, Napoli, Italy. Electronic address: caterina.missero@unina.it.

PMID: 30471766
DOI: 10.1016/j.jisp.2018.10.004

Abstract

The p53 family member p63 is a master regulator of gene expression in stratified epithelia, such as the epidermis. One of the main functions of p63 is to sustain mechanical resistance, positively regulating several epidermal genes involved in cell-matrix adhesion and cell-cell adhesion (Ferone et al., 2015).

Grants and funding

GGP09230/TI_/Telethon/Italy