Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR

Clin Chem. 2019 Feb;65(2):345-347. doi: 10.1373/clinchem.2018.293548. Epub 2018 Dec 5.

Authors

Fulya Taylan¹, Benedicte Bang², Ingegerd Ivanov Öfverholm^{2

3}, Anh-Nhi Tran^{2

3}, Mats Heyman⁴, Gisela Barbany^{2

3}, Vasilios Zachariadis², Ann Nordgren^{2

3}

Affiliations

¹ Department of Molecular Medicine and Surgery Center for Molecular Medicine Karolinska Institutet Stockholm, Sweden fulya.taylan@ki.se.
² Department of Molecular Medicine and Surgery Center for Molecular Medicine Karolinska Institutet Stockholm, Sweden.
³ Diagnostic Services Karolinska University Hospital Clinical Genetics Stockholm, Sweden.
⁴ Department of Women's and Children's Health Karolinska University Hospital Solna Stockholm, Sweden.

PMID: 30518665
DOI: 10.1373/clinchem.2018.293548

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow Cells / metabolism
Child, Preschool
Chromosome Aberrations
DNA / chemistry*
DNA / metabolism
Dried Blood Spot Testing
Histone-Lysine N-Methyltransferase / genetics
Humans
Infant
Infant, Newborn
Leukemia / diagnosis*
Leukemia / genetics
Limit of Detection
Myeloid-Lymphoid Leukemia Protein / genetics
Polymerase Chain Reaction
Whole Genome Sequencing / methods*

Substances

KMT2A protein, human
Myeloid-Lymphoid Leukemia Protein
DNA
Histone-Lysine N-Methyltransferase