Initiation and Evolution of Early Onset Prostate Cancer

Cancer Cell. 2018 Dec 10;34(6):874-876. doi: 10.1016/j.ccell.2018.11.010.

Abstract

In this issue of Cancer Cell, Gerhauser et al. analyze early-onset prostate cancers, showing roles for androgen receptor-driven rearrangements, an early APOBEC-driven mutational mechanism, and ESRP1 gene duplication. Through integration of whole-genome, transcriptome, and methylome data, they identify high-risk subgroups and develop an algorithm that may predict molecular evolution.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Evolution, Molecular
  • Humans
  • Male
  • Mutation
  • Prostatic Neoplasms*
  • Receptors, Androgen / genetics*
  • Transcriptome

Substances

  • Receptors, Androgen