EGR-mediated control of STIM expression and function

Cell Calcium. 2019 Jan:77:58-67. doi: 10.1016/j.ceca.2018.12.003. Epub 2018 Dec 6.

Abstract

Ca2+ is a ubiquitous, dynamic and pluripotent second messenger with highly context-dependent roles in complex cellular processes such as differentiation, proliferation, and cell death. These Ca2+ signals are generated by Ca2+-permeable channels located on the plasma membrane (PM) and endoplasmic reticulum (ER) and shaped by PM- and ER-localized pumps and transporters. Differences in the expression of these Ca2+ homeostasis proteins contribute to cell and context-dependent differences in the spatiotemporal organization of Ca2+ signals and, ultimately, cell fate. This review focuses on the Early Growth Response (EGR) family of zinc finger transcription factors and their role in the transcriptional regulation of Stromal Interaction Molecule (STIM1), a critical regulator of Ca2+ entry in both excitable and non-excitable cells.

Keywords: Calcium signaling; Early growth response factors; PMCA; STIM1; Store-operated calcium entry.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling*
  • Cell Membrane / metabolism*
  • Early Growth Response Transcription Factors / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Neoplasm Proteins / biosynthesis*
  • Stromal Interaction Molecule 1 / biosynthesis*

Substances

  • Early Growth Response Transcription Factors
  • Neoplasm Proteins
  • STIM1 protein, human
  • Stromal Interaction Molecule 1
  • Calcium