A Cluster of Cefepime-induced Neutropenia During Outpatient Parenteral Antimicrobial Therapy

Clin Infect Dis. 2019 Jul 18;69(3):534-537. doi: 10.1093/cid/ciy1112.

Abstract

A cluster of cefepime-induced neutropenia (CIN) was identified from June 2017 to May 2018 in a regional outpatient parenteral antimicrobial therapy population. Our data suggest prolonged courses of cefepime (≥2 weeks), administered by rapid intravenous push, were associated with a higher risk of CIN.

Keywords: OPAT; adverse drug event; cefepime; cefepime-induced neutropenia; drug-induced neutropenia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Cefepime / adverse effects*
  • Cefepime / therapeutic use
  • Female
  • Humans
  • Infusions, Intravenous / adverse effects
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Neutropenia / chemically induced*
  • Outpatients
  • Retrospective Studies
  • Risk Factors

Substances

  • Anti-Bacterial Agents
  • Cefepime