Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

J Cell Biol. 2019 Mar 4;218(3):742-756. doi: 10.1083/jcb.201810103. Epub 2018 Dec 31.

Abstract

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites. Multidomain scaffolding proteins nucleate assembly and direct localization of these complexes, and the protein Scribble and its relatives in the LAP protein family provide a paradigm for this. Scribble was originally identified because of its role in apical-basal polarity and epithelial integrity in Drosophila melanogaster It is now clear that Scribble acts to assemble and position diverse multiprotein complexes in processes ranging from planar polarity to adhesion to oriented cell division to synaptogenesis. Here, we explore what we have learned about the mechanisms of action of Scribble in the context of its multiple known interacting partners and discuss how this knowledge opens new questions about the full range of Scribble protein partners and their structural and signaling roles.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cell Polarity / physiology*
  • Cell Proliferation / physiology*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster
  • Membrane Proteins / metabolism*
  • Multiprotein Complexes / metabolism
  • Signal Transduction / physiology*

Substances

  • Drosophila Proteins
  • Membrane Proteins
  • Multiprotein Complexes
  • Scrib protein, Drosophila