Evidence for a predominant renal secretion and clearance of inactive plasma renin, studied by in vivo inhibition of protein synthesis, and inhibition of renal tubular protein reabsorption

Clin Exp Hypertens A. 1988;10(6):1301-3. doi: 10.1080/07300077.1988.11878925.

Abstract

Inactive plasma renin is mainly secreted and eliminated by the kidneys in the mouse. The half-life of inactive plasma renin is 6 hours or less. The kidneys remove inactive renin from the circulation by glomerular ultrafiltration.

MeSH terms

  • Absorption
  • Animals
  • Enzyme Precursors / blood*
  • Enzyme Precursors / metabolism
  • Kidney / metabolism*
  • Kidney Tubules / metabolism*
  • Mice
  • Renin / blood*
  • Renin / metabolism

Substances

  • Enzyme Precursors
  • Renin