The World Health Organization(WHO)has set the goal to eliminate viral hepatitis as a public health threat by 2030, and the key to achieve this ambitious goal lies on the standardized and precise management of pregnant women and their infants by effectively blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Standardized management includes screening and antiviral intervention during pregnancy, infant immunization, and evaluation of immune effect, breastfeeding and mode of delivery. The results of randomized controlled clinical trials and real-world data have confirmed that the comprehensive prevention strategy based on combined immune prophylaxis of neonates can effectively block MTCT of HBV. It is one of the key links to eliminate viral hepatitis in our country, and to formulate a new strategy in line with the public health needs at home and abroad and thereby promote the implementation and application of standardized management process to improve the public's awareness of the disease.
世界卫生组织提出到2030年要实现消除病毒性肝炎对公共卫生威胁的目标，而实现这一宏伟目标的关键在于通过对孕产妇及其新生儿的规范化、精细化管理以有效阻断乙型肝炎母婴传播。规范化管理包括妊娠期筛查、抗病毒干预、婴儿免疫接种、免疫效果的评价以及母乳喂养、分娩方式的选择等重要环节。临床随机对照研究和真实世界临床实践数据结果均已证实，以新生儿联合免疫为基础的综合预防策略能够完全阻断乙型肝炎的母婴传播。制定符合国内外公共卫生需求的新策略，提高公众的疾病认知度，推动规范化管理流程的实施和运用，是当前我国消除病毒性肝炎危害工作的重点环节之一。.
Keywords: Hepatitis B; Hepatitis B virus; Mother-to-child transmission; Shield project aiming zero mother-to-child transmission of hepatitis B virus.