Neuroscientific information may transform the modern practice of psychotherapy. Still we must pay heed to the most salient of the common factors generating therapeutic change: the relationship between patient and therapist. Likewise, brain and body are both part of mind and we ignore this at our clinical peril. Research on affective, cognitive, mnemic, somatic, psychophysiologic, developmental, and integrative mental processes, amongst others, must hold to a high standard of translation from basic scientific findings or we risk practicing a psychotherapy enslaved to an authoritarian scientism as a substitute for the creation of unfettered intimacy and engagement. A balanced approach is required if in trauma treatment, for example, we are to be both potential beneficiaries of understanding what is in our human heads while not losing track of our very human hearts. Each clinician need develop a basic knowledge of neuroscience in order to critically assess the meanings of new findings and their proper place in the practice of all the psychotherapies.