Abstract
We report the design and fabrication of a multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor. The integration of the dual-stimulus of an acidic microenvironment and laser irradiation with the triple-synergistic therapy of doxorubicin, photothermal and siRNA offers excellent therapeutic performance for drug resistant tumor cells with high specificity and little side effects.
MeSH terms
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / adverse effects
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Antitubercular Agents / therapeutic use*
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Cell Line, Tumor
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Combined Modality Therapy / methods*
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Doxorubicin / therapeutic use*
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Drug Carriers / chemistry
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Drug Liberation
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Drug Resistance, Neoplasm
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Drug Therapy / methods
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Folic Acid / chemistry
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Genetic Therapy / methods
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Humans
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Indoles / chemistry
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Luminescent Agents / administration & dosage
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Luminescent Agents / adverse effects
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Luminescent Agents / therapeutic use*
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Nanoparticles / chemistry
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Optical Imaging / methods
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Particle Size
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Phototherapy / methods
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Polyethyleneimine / chemistry
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Polymers / chemistry
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RNA, Small Interfering / administration & dosage
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RNA, Small Interfering / adverse effects
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RNA, Small Interfering / therapeutic use*
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Surface Properties
Substances
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Antitubercular Agents
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Drug Carriers
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Indoles
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Luminescent Agents
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Polymers
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RNA, Small Interfering
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polydopamine
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Doxorubicin
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Polyethyleneimine
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Folic Acid