Ultrashort echo time magnetic resonance fingerprinting (UTE-MRF) for simultaneous quantification of long and ultrashort T2 tissues

Abstract

Purpose: To demonstrate an ultrashort echo time magnetic resonance fingerprinting (UTE-MRF) method that allows quantifying relaxation times for muscle and bone in the musculoskeletal system and generating bone enhanced images that mimic CT scans.

Methods: A fast imaging steady-state free precession MRF sequence with half pulse excitation and half projection readout was designed to sample fast T₂ decay signals. Varying echo time (TE) of a sinusoidal pattern was applied to enhance sensitivity for tissues with short and ultrashort T₂ values. The performance of UTE-MRF was evaluated via simulations, phantom, and in vivo experiments.

Results: A minimal TE of 0.05 ms was achieved. Simulations indicated the sinusoidal TE sampling increased T₂ quantification accuracy in the cortical bone and tendon but had little impact on long T₂ muscle quantifications. For the rubber phantom, the averaged relaxometries from UTE-MRF (T₁ = 162 ms and T₂ = 1.07 ms) compared well with the gold standard (T₁ = 190 ms and ${\text{T}}_2^{\ast }$ = 1.03 ms). For the long T₂ agarose phantom, the linear regression slope between UTE-MRF and gold standard was 1.07 (R² = 0.991) for T₁ and 1.04 (R² = 0.994) for T₂ . In vivo experiments showed the detection of the cortical bone (averaged T₂ = 1.0 ms) and Achilles tendon (averaged T₂ = 15 ms). Scalp structures from the bone enhanced image show high similarity with CT.

Conclusion: The UTE-MRF with sinusoidal TEs can simultaneously quantify T₁ , T₂ , proton density, and B₀ in long, short, even ultrashort T₂ musculoskeletal structures. Bone enhanced images can be achieved in the brain with UTE-MRF.

Keywords: bone enhanced image; magnetic resonance fingerprinting; sinusoidal TE variation; ultrashort echo time.