Abstract
A group A xeroderma pigmentosum revertant with normal sensitivity was created by chemical mutagenesis. It repaired (6-4) photoproducts normally but not pyrimidine dimers and had near normal levels of repair replication, sister chromatid exchange, and mutagenesis from UV light. The rate of UV-induced mutation in a shuttle vector, however, was as high as the rate in the parental xeroderma pigmentosum cell line.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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4-Nitroquinoline-1-oxide
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Cell Line, Transformed
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DNA Repair*
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Humans
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Methylnitronitrosoguanidine
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Mutation / drug effects
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Mutation / radiation effects
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Pyrimidine Dimers
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Sister Chromatid Exchange
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Ultraviolet Rays
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Xeroderma Pigmentosum / genetics*
Substances
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Pyrimidine Dimers
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Methylnitronitrosoguanidine
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4-Nitroquinoline-1-oxide