With improved care, the number of sickle cell patients with obesity is increasing. The experience with bariatric surgery in this patient population is limited. We describe four adult patients with mild sickling genotypes who underwent laparoscopic sleeve gastrectomy. The patients achieved marked weight loss with percentage of excess weight loss ranging from 56 to 68%. The surgery was associated with decreases in white blood cell counts and lower random glucose concentrations. No short-term or long-term complications related to the surgery were observed. Our report supports bariatric surgery as a feasible weight-loss option in this patient population.
Keywords: Bariatric surgery; Glucose; Sickle cell disease; White blood cell.