The roles of Orai and Stim in bone health and disease

Cell Calcium. 2019 Jul:81:51-58. doi: 10.1016/j.ceca.2019.06.001. Epub 2019 Jun 5.

Abstract

Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.

Keywords: Bone remodeling; Mineralization; Osteogenesis; Osteoporosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Density
  • Bone Remodeling
  • Calcium Signaling
  • Homeostasis
  • Humans
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • ORAI1 Protein / genetics
  • ORAI1 Protein / metabolism*
  • Osteogenesis
  • Osteoporosis / genetics
  • Osteoporosis / metabolism*
  • Stromal Interaction Molecule 1 / genetics
  • Stromal Interaction Molecule 1 / metabolism*

Substances

  • Neoplasm Proteins
  • ORAI1 Protein
  • ORAI1 protein, human
  • STIM1 protein, human
  • Stromal Interaction Molecule 1