Macropinocytosis in Cancer: A Complex Signaling Network

Trends Cancer. 2019 Jun;5(6):332-334. doi: 10.1016/j.trecan.2019.04.002. Epub 2019 May 9.

Abstract

Macropinocytosis is an important nutrient-scavenging pathway in numerous cancer types, including pancreatic, lung, prostate, and bladder. This Forum highlights recent work identifying the key regulators of macropinocytosis that support tumor cell fitness in different contexts, providing a unique framework for strategies to target macropinocytosis in the treatment of cancer.

Keywords: AMPK; PTEN; Ras; Wnt; integrin αvβ3; macropinocytosis; metabolism.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Disease Models, Animal
  • Heterografts
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Pinocytosis / genetics*
  • Pinocytosis / immunology*
  • Signal Transduction*

Substances

  • Biomarkers, Tumor