[Reduced sensitivity of the heart ventricle of obese Zucker rats to isoprenaline]

C Vernimmen; M C Auclair; P Lechat

[Reduced sensitivity of the heart ventricle of obese Zucker rats to isoprenaline]

C R Acad Sci III. 1988;306(4):153-6.

[Article in French]

Authors

C Vernimmen¹, M C Auclair, P Lechat

Affiliation

¹ Institut de Pharmacologie et Unité n. 228 I.N.S.E.R.M., Paris.

PMID: 3129149

Abstract

In heart of genetically obese (fa/fa) 12-week-old Zucker rats, ventricle contractility (4 mM KCl medium), amplitude and duration of slow action potentials (14 mM KCl medium) were less increased by isoprenaline than in heart of non obese (Fa/fa) rats. This difference could be related to a lower reactivity of beta-adrenoceptors in obese rat heart.

Publication types

Comparative Study
English Abstract

MeSH terms

Action Potentials / drug effects
Animals
Heart / drug effects
Heart / physiology*
Heart Ventricles / drug effects
Heart Ventricles / physiopathology
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects
Obesity / physiopathology*
Rats
Rats, Mutant Strains
Rats, Zucker
Ventricular Function

Substances

Isoproterenol