Despite the major improvements in clinical dentistry, resulting from dental science efforts to shape current clinical dentistry, it has been almost forty years since a new therapy has reached dental practice. The focused scientific effort on evolving dental materials and equipment to facilitate their use has overshadowed the most important aim for developing new dental techniques: human biology. This opinion piece argues a new mindset in dentistry is crucial for the birthing of innovative treatments. It also discusses the path for a new era of dentistry that welcomes new biologically based approaches, including whole dental pulp and bioengineered tooth regeneration, currently being tested in cutting-edge laboratories around the world. Suggestions will be made to justify the reason clinicians must be educated in molecular biology and how universities and the General Dental Council need to prepare in-qualification or qualified dentists. A new biologically-based era of dentistry is around the corner and dentistry as we know it is changing forever.