The effect of ageing on the resolution of inflammation

Wezi Sendama

doi:10.1016/j.arr.2019.101000

The effect of ageing on the resolution of inflammation

Ageing Res Rev. 2020 Jan:57:101000. doi: 10.1016/j.arr.2019.101000. Epub 2019 Dec 17.

Author

Wezi Sendama¹

Affiliation

¹ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, United Kingdom. Electronic address: wezi.sendama@newcastle.ac.uk.

Abstract

Ageing is associated with the development of a low-level, systemic, chronic inflammation known as "inflammaging". This chronic inflammatory state can contribute to diseases of ageing such as sarcopenia and frailty. The presence of inflammaging suggests a failure of the cell clearance mechanisms that ordinarily aid in the resolution of inflammation after pathogen infiltration or tissue injury. This review aims to explore what is known of how the processes involved in the resolution of inflammation might become defective with age.

Keywords: Ageing; Apoptosis; Efferocytosis; Inflammaging; Resolution of inflammation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / immunology*
Animals
Apoptosis
Frailty
Humans
Immunosenescence
Inflammation*
Sarcopenia

Abstract

Publication types

MeSH terms

Grants and funding