Abstract
Since the widespread introduction of the conjugate pneumococcal vaccine and subsequent decline of invasive pneumococcal disease in children, a significant proportion of children with pneumococcal meningitis are identified as having an underlying immunodeficiency or predisposing anatomic abnormality. We present 3 cases of recurrent pneumococcal meningitis where detailed neuro-imaging revealed subtle anterior base of skull defects not detected on initial investigations.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Biomarkers
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Child, Preschool
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Female
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Humans
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Leukocyte Count
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Magnetic Resonance Imaging
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Male
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Meningitis, Pneumococcal / diagnosis*
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Meningitis, Pneumococcal / drug therapy
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Meningitis, Pneumococcal / etiology*
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Meningitis, Pneumococcal / prevention & control
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Meningocele / complications*
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Meningocele / diagnosis
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Meningocele / surgery
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Pneumococcal Vaccines / immunology
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Recurrence
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Tomography, X-Ray Computed
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Biomarkers
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Pneumococcal Vaccines