Vasomotion Drives Periarterial Drainage of Aβ from the Brain

Roxana O Carare; Roxana Aldea; Diederik Bulters; Aiman Alzetani; Anthony A Birch; Giles Richardson; Roy O Weller

doi:10.1016/j.neuron.2020.01.011

Vasomotion Drives Periarterial Drainage of Aβ from the Brain

Neuron. 2020 Feb 5;105(3):400-401. doi: 10.1016/j.neuron.2020.01.011.

Authors

Roxana O Carare¹, Roxana Aldea², Diederik Bulters³, Aiman Alzetani³, Anthony A Birch³, Giles Richardson⁴, Roy O Weller⁴

Affiliations

¹ University of Southampton, Southampton, UK. Electronic address: rcn@soton.ac.uk.
² University of Southampton, Southampton, UK; Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.
³ Southampton University Hospital Trust, Southampton, UK.
⁴ University of Southampton, Southampton, UK.

PMID: 32027828
DOI: 10.1016/j.neuron.2020.01.011

Abstract

In this issue of Neuron, van Veluw et al. (2020) show that elimination of solutes from the brain along arterial walls is driven by low-frequency arteriolar oscillations and suggest that age-related reduction of this vasomotion may contribute to impaired clearance of Aβ.

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MeSH terms

Animals
Arterioles
Brain*
Drainage
Mice
Wakefulness*