Combinatorial metabolism drives the naive to primed pluripotent chromatin landscape

Exp Cell Res. 2020 Apr 15;389(2):111913. doi: 10.1016/j.yexcr.2020.111913. Epub 2020 Feb 19.

Abstract

Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled. Interestingly, recent studies have revealed metabolic regulation for epigenetic modifications in pluripotent cells. As metabolic differences are prominent between naive (pre-implantation) and primed (post-implantation) pluripotent cells, the epigenetic changes regulated by metabolites has become an interesting topic of analysis. In this review we discuss how combinatorial metabolic activities drive the developmental progression through early pluripotent stages.

Keywords: Epigenetics; Metabolism; Naive; Postimplantation; Preimplantation; Primed; Stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blastocyst / cytology*
  • Blastocyst / metabolism
  • Cell Differentiation
  • Chromatin / genetics*
  • Embryonic Stem Cells / cytology*
  • Embryonic Stem Cells / metabolism
  • Epigenesis, Genetic*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Metabolome*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism

Substances

  • Chromatin