Osteoporosis Management in the Era of COVID-19

J Bone Miner Res. 2020 Jun;35(6):1009-1013. doi: 10.1002/jbmr.4049. Epub 2020 May 26.

Abstract

Osteoporosis is a chronic condition that reflects reduced bone strength and an associated increased risk for fracture. As a chronic condition, osteoporosis generally requires sustained medical intervention(s) to limit the risks for additional bone loss, compromise of skeletal integrity, and fracture occurrence. Further complicating this issue is the fact that the abrupt cessation of some therapies can be associated with an increased risk for harm. It is in this context that the COVID-19 pandemic has brought unprecedented disruption to the provision of health care globally, including near universal requirements for social distancing. In this Perspective, we provide evidence, where available, regarding the general care of patients with osteoporosis in the COVID-19 era and provide clinical recommendations based primarily on expert opinion when data are absent. Particular emphasis is placed on the transition from parenteral osteoporosis therapies. It is hoped that these recommendations can be used to safely guide care for patients with osteoporosis until a return to routine clinical care standards is available. © 2020 American Society for Bone and Mineral Research.

Keywords: ABALOPARATIDE; BISPHOSPHONAT; COVID-19; DENOSUMAB; FRACTURES; OSTEOPOROSIS; ROMOSOZUMAB; TERIPARATIDE.

Publication types

  • Congress
  • Practice Guideline

MeSH terms

  • Absorptiometry, Photon
  • Biomarkers / blood
  • Bone Density
  • Bone Density Conservation Agents / administration & dosage
  • Bone Density Conservation Agents / adverse effects
  • Bone Density Conservation Agents / therapeutic use
  • COVID-19
  • Continuity of Patient Care
  • Coronavirus Infections* / blood
  • Coronavirus Infections* / complications
  • Denosumab / adverse effects
  • Denosumab / therapeutic use
  • Disease Management
  • Drug Administration Schedule
  • Estrogen Replacement Therapy / adverse effects
  • Fractures, Spontaneous / prevention & control
  • Fractures, Spontaneous / therapy
  • Home Care Services
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Osteoporosis / blood
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / drug therapy
  • Osteoporosis / therapy*
  • Pandemics*
  • Pneumonia, Viral* / blood
  • Pneumonia, Viral* / complications
  • Raloxifene Hydrochloride / adverse effects
  • Raloxifene Hydrochloride / therapeutic use
  • Recurrence
  • Telemedicine
  • Thrombophilia / chemically induced
  • Thrombophilia / etiology
  • Unnecessary Procedures

Substances

  • Biomarkers
  • Bone Density Conservation Agents
  • Denosumab
  • Raloxifene Hydrochloride