Managing Hyperosmotic Stress through Phase Separation

Ivan Peran; Nafiseh Sabri; Tanja Mittag

doi:10.1016/j.tibs.2020.05.004

Managing Hyperosmotic Stress through Phase Separation

Trends Biochem Sci. 2020 Sep;45(9):721-723. doi: 10.1016/j.tibs.2020.05.004. Epub 2020 May 21.

Authors

Ivan Peran¹, Nafiseh Sabri¹, Tanja Mittag²

Affiliations

¹ Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
² Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: tanja.mittag@stjude.org.

PMID: 32446814
DOI: 10.1016/j.tibs.2020.05.004

Abstract

In a recent study, Yasuda et al. show how liquid-liquid phase separation (LLPS) under hyperosmotic stress conditions allows cells to react to ubiquitinated proteins and to assemble nuclear, liquid compartments that recruit proteasomes and result in aggregate clearance.

Publication types

Comment

MeSH terms

Cell Nucleus*
Proteasome Endopeptidase Complex*
Ubiquitination

Substances

Proteasome Endopeptidase Complex