SnapShot: Ferroptosis

Kamyar Hadian; Brent R Stockwell

doi:10.1016/j.cell.2020.04.039

SnapShot: Ferroptosis

Cell. 2020 May 28;181(5):1188-1188.e1. doi: 10.1016/j.cell.2020.04.039.

Authors

Kamyar Hadian¹, Brent R Stockwell²

Affiliations

¹ Assay Development and Screening Platform, Helmholtz Zentrum Mu¨nchen, Neuherberg, Germany.
² Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA.

Abstract

Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation. This SnapShot provides an overview of ferroptosis-related pathways, including relevant biomolecules and small-molecule modulators regulating them.

MeSH terms

Cell Death
Ferroptosis / genetics*
Ferroptosis / physiology*
Humans
Iron / metabolism*
Lipid Peroxidation / physiology
Oxidation-Reduction
Phospholipids / metabolism

Substances

Phospholipids
Iron

Abstract

MeSH terms

Substances

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