Cap-Snatching Leads to Novel Viral Proteins

Cell. 2020 Jun 25;181(7):1450-1451. doi: 10.1016/j.cell.2020.05.044.

Abstract

Some negative-sense RNA viruses prime mRNA transcription using host 5' cap sequences, usurping host translational machinery and evading antiviral surveillance. In this issue of Cell, Ho et al. identify an additional consequence of this viral strategy: the acquisition of upstream start codons from host-derived sequences and subsequent translation of novel viral products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • RNA Caps*
  • RNA, Messenger
  • RNA, Viral / genetics
  • Recombinant Fusion Proteins
  • Viral Proteins* / genetics

Substances

  • RNA Caps
  • RNA, Messenger
  • RNA, Viral
  • Recombinant Fusion Proteins
  • Viral Proteins