Oncogenes Feed Treg Cells without Calling CD8s to the Table

Immunity. 2020 Jul 14;53(1):13-15. doi: 10.1016/j.immuni.2020.06.020.

Abstract

Metabolic support for regulatory T (Treg) cells in noninflamed tumors is not well understood. In this issue of Immunity, Kumagai et. al. show how oncogene-driven fatty-acid synthesis favors Treg cells over effector T cells and how this imbalance can be overcome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Neoplasms*
  • Oncogenes
  • T-Lymphocytes, Regulatory*
  • Tumor Microenvironment