Oncogenes Feed Treg Cells without Calling CD8s to the Table

Nikhil Khatwani; Mary Jo Turk

doi:10.1016/j.immuni.2020.06.020

Oncogenes Feed Treg Cells without Calling CD8s to the Table

Immunity. 2020 Jul 14;53(1):13-15. doi: 10.1016/j.immuni.2020.06.020.

Authors

Nikhil Khatwani¹, Mary Jo Turk²

Affiliations

¹ Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
² Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. Electronic address: mary.jo.turk@dartmouth.edu.

PMID: 32668223
DOI: 10.1016/j.immuni.2020.06.020

Abstract

Metabolic support for regulatory T (Treg) cells in noninflamed tumors is not well understood. In this issue of Immunity, Kumagai et. al. show how oncogene-driven fatty-acid synthesis favors Treg cells over effector T cells and how this imbalance can be overcome.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Neoplasms*
Oncogenes
T-Lymphocytes, Regulatory*
Tumor Microenvironment

Grants and funding

R01 CA225028/CA/NCI NIH HHS/United States