Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

Oksana Minyaylo; Dina Starikova; Maria Moskalenko; Irina Ponomarenko; Evgeny Reshetnikov; Volodymyr Dvornyk; Mikhail Churnosov

doi:10.1016/j.dib.2020.106004

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

Data Brief. 2020 Jul 8:31:106004. doi: 10.1016/j.dib.2020.106004. eCollection 2020 Aug.

Authors

Oksana Minyaylo¹, Dina Starikova¹, Maria Moskalenko¹, Irina Ponomarenko¹, Evgeny Reshetnikov¹, Volodymyr Dvornyk², Mikhail Churnosov¹

Affiliations

¹ Department of Medical Biological Disciplines, Belgorod State University, Belgorod 308015, Russia.
² Department of Life Sciences, College of Science and General Studies, Alfaisal University, Riyadh 11533, Saudi Arabia.

Abstract

Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases (MMP) genes (rs1799750 MMP1, rs3918242 and rs17576 MMP9) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented. Association studies identified these SNPs as possible significant markers associated with many multifactorial disorders, including POAG, EH, and PU. The frequencies of alleles and genotypes of the three SNPs in Russian patients with POAG, EH, and PU were presented separately for the entire study sample, females, and males, respectively. The data can be used as a reference for the Russian population.

Keywords: Essential hypertension; MMP; Peptic ulcer; Primary open-angle glaucoma; Single nucleotide polymorphism.