Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation

Patrick Fernandes Rodrigues; Roxane Tussiwand

doi:10.1016/j.molimm.2020.07.006

Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation

Mol Immunol. 2020 Oct:126:25-30. doi: 10.1016/j.molimm.2020.07.006. Epub 2020 Jul 30.

Authors

Patrick Fernandes Rodrigues¹, Roxane Tussiwand²

Affiliations

¹ Department of Biomedicine, University of Basel, 4058, Basel, Switzerland.
² Department of Biomedicine, University of Basel, 4058, Basel, Switzerland; Laboratory of Immune Regulation, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: roxane.tussiwand@nih.gov.

PMID: 32739721
DOI: 10.1016/j.molimm.2020.07.006

Abstract

Plasmacytoid dendritic cells (pDCs) are an immune subset specialized in the production of Type I Interferons (IFNs). They are characterized by co-expression of myeloid and lymphoid markers. Their developmental origin has been studied since their discovery and the identification of a myeloid progenitor capable of generating all dendritic cell (DC) subsets, including pDCs, led to their classification within the myeloid compartment. However, recent findings challenge this hypothesis and provide evidence for a lymphoid origin for the majority of pDCs ^46-48. In this review we discuss and present the original myeloid and the newer lymphoid developmental trajectories of pDCs.

Keywords: Development; Hematopoiesis; Lymphoid; Myeloid; pDC.

Publication types

Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / immunology*
Cell Lineage / immunology*
Cell Lineage / physiology*
Dendritic Cells / physiology*
Humans
Lymphoid Progenitor Cells / physiology*
Myeloid Progenitor Cells