RSSs set the odds for exclusion

J Exp Med. 2020 Sep 7;217(9):e20200831. doi: 10.1084/jem.20200831.

Abstract

In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Alleles
  • Protein Sorting Signals*
  • Receptors, Antigen, T-Cell, alpha-beta* / genetics
  • Recombination, Genetic

Substances

  • Protein Sorting Signals
  • Receptors, Antigen, T-Cell, alpha-beta