"Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era

Annu Rev Psychol. 2021 Jan 4:72:37-60. doi: 10.1146/annurev-psych-052220-103822. Epub 2020 Sep 8.

Abstract

Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.

Keywords: behavior genetics; gene × environment interaction; genome-wide association study; heritability; polygenic scores; twin studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Genetics, Behavioral*
  • Genome-Wide Association Study
  • Humans
  • Multifactorial Inheritance
  • Twin Studies as Topic